abstract：:Recent studies have emphasized the association of adipose oxidative stress (Fat reactive oxygen species [ROS]) with the pathogenesis of metabolic disorders in obesity. However, the causal roles of Fat ROS in metabolic disturbances in vivo remain unclear because no mouse model has been available in which oxidative stre...

journal_title：Diabetes

authors： Okuno Y,Fukuhara A,Hashimoto E,Kobayashi H,Kobayashi S,Otsuki M,Shimomura I

更新日期：2018-06-01 00:00:00

abstract：:Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity. This includes specific subpopulations with d...

journal_title：Diabetes

authors： Benninger RKP,Hodson DJ

更新日期：2018-04-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotoci...

journal_title：Diabetes

authors： Kim YB,Kim WB,Jung WW,Jin X,Kim YS,Kim B,Han HC,Block GD,Colwell CS,Kim YI

更新日期：2018-03-01 00:00:00

abstract：:Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31+CD14+CD34+ monocyte subset via three-dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the effica...

journal_title：Diabetes

authors： Oh BJ,Jin SM,Hwang Y,Choi JM,Lee HS,Kim G,Kim G,Park HJ,Kim P,Kim SJ,Kim JH

更新日期：2018-03-01 00:00:00

abstract：:Therapeutic engineering of glucagon-like peptide 1 (GLP-1) has enabled development of new medicines to treat type 2 diabetes. These injectable analogs achieve robust glycemic control by increasing concentrations of "GLP-1 equivalents" (∼50 pmol/L). Similar levels of endogenous GLP-1 occur after gastric bypass surgery,...

journal_title：Diabetes

authors： Briere DA,Bueno AB,Gunn EJ,Michael MD,Sloop KW

更新日期：2018-02-01 00:00:00

abstract：:The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in...

journal_title：Diabetes

authors： Dunmore SJ,Al-Derawi AS,Nayak AU,Narshi A,Nevill AM,Hellwig A,Majebi A,Kirkham P,Brown JE,Singh BM

更新日期：2018-01-01 00:00:00

abstract：:AMPK is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. In this study, we discovered a functional link between AMPK and T...

journal_title：Diabetes

authors： Wang S,Kobayashi K,Kogure Y,Yamanaka H,Yamamoto S,Yagi H,Noguchi K,Dai Y

更新日期：2018-01-01 00:00:00

abstract：:Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through de novo adipogenesis; however, how "beiging" characteristics are...

journal_title：Diabetes

authors： Wang Y,Paulo E,Wu D,Wu Y,Huang W,Chawla A,Wang B

更新日期：2017-12-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells respond to an insulin...

journal_title：Diabetes

authors： Spanier JA,Sahli NL,Wilson JC,Martinov T,Dileepan T,Burrack AL,Finger EB,Blazar BR,Michels AW,Moran A,Jenkins MK,Fife BT

更新日期：2017-12-01 00:00:00

abstract：:This article seeks to determine whether factors related to autoimmunity risk remain significant after the initiation of two or more diabetes-related autoantibodies and continue to contribute to type 1 diabetes (T1D) risk among autoantibody-positive children in The Environmental Determinants of Diabetes in the Young (T...

journal_title：Diabetes

authors： Krischer JP,Liu X,Lernmark Å,Hagopian WA,Rewers MJ,She JX,Toppari J,Ziegler AG,Akolkar B,TEDDY Study Group.

更新日期：2017-12-01 00:00:00

abstract：:Pancreatic islets produce and secrete cytokines and chemokines in response to inflammatory and metabolic stress. The physiological role of these "isletokines" in health and disease is largely unknown. We observed that islets release multiple inflammatory mediators in patients undergoing islet transplants within hours ...

journal_title：Diabetes

authors： Yoshimatsu G,Kunnathodi F,Saravanan PB,Shahbazov R,Chang C,Darden CM,Zurawski S,Boyuk G,Kanak MA,Levy MF,Naziruddin B,Lawrence MC

更新日期：2017-11-01 00:00:00

abstract：:This cross-sectional study evaluated the relationship between 1) functional and structural measurements of neurodegeneration in the initial stages of diabetic retinopathy (DR) and 2) the presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of 449 patients with type 2 diabetes enr...

journal_title：Diabetes

authors： Santos AR,Ribeiro L,Bandello F,Lattanzio R,Egan C,Frydkjaer-Olsen U,García-Arumí J,Gibson J,Grauslund J,Harding SP,Lang GE,Massin P,Midena E,Scanlon P,Aldington SJ,Simão S,Schwartz C,Ponsati B,Porta M,Costa MÂ,Her

更新日期：2017-09-01 00:00:00

abstract：:Methylglyoxal (MGO), a major precursor for advanced glycation end products, is increased in diabetes. In diabetic rodents, inhibition of MGO prevents cardiovascular disease (CVD). Whether plasma MGO levels are associated with incident CVD in people with type 1 diabetes is unknown. We included 159 individuals with pers...

journal_title：Diabetes

authors： Hanssen NMJ,Scheijen JLJM,Jorsal A,Parving HH,Tarnow L,Rossing P,Stehouwer CDA,Schalkwijk CG

更新日期：2017-08-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is associated with hepatic insulin resistance and may result primarily from increased hepatic de novo lipogenesis (PRIM) or secondarily from adipose tissue lipolysis (SEC). We studied mice with hepatocyte- or adipocyte-specific SREBP-1c overexpression as models of PRIM and SEC. PRIM mi...

journal_title：Diabetes

authors： Jelenik T,Kaul K,Séquaris G,Flögel U,Phielix E,Kotzka J,Knebel B,Fahlbusch P,Hörbelt T,Lehr S,Reinbeck AL,Müller-Wieland D,Esposito I,Shulman GI,Szendroedi J,Roden M

更新日期：2017-08-01 00:00:00

abstract：:The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knockout mouse model to test the hypothesis that Sox4 is essential for the m...

journal_title：Diabetes

authors： Xu EE,Sasaki S,Speckmann T,Nian C,Lynn FC

更新日期：2017-08-01 00:00:00

abstract：:We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance. We assessed insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrial-targeted catalase (MCAT) that were fed regular chow (RC) or a high-fat diet (HFD) or underwent an acute ...

journal_title：Diabetes

authors： Lee HY,Lee JS,Alves T,Ladiges W,Rabinovitch PS,Jurczak MJ,Choi CS,Shulman GI,Samuel VT

更新日期：2017-08-01 00:00:00

abstract：:Dysfunctional T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of autoimmune T cells in the blood hinder their study. We describe a method to enrich and harvest autoimmune T cells in vivo by using a biomaterial scaffold loaded with protein antigens. In model antigen system...

journal_title：Diabetes

authors： Thelin MA,Kissler S,Vigneault F,Watters AL,White D,Koshy ST,Vermillion SA,Mooney DJ,Serwold T,Ali OA

更新日期：2017-08-01 00:00:00

abstract：:We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia, oxidative stress,...

journal_title：Diabetes

authors： Lo CS,Shi Y,Chenier I,Ghosh A,Wu CH,Cailhier JF,Ethier J,Lattouf JB,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

更新日期：2017-07-01 00:00:00

abstract：:Islet β-cells adapt to insulin resistance through increased insulin secretion and expansion. Type 2 diabetes typically occurs when prolonged insulin resistance exceeds the adaptive capacity of β-cells. Our prior screening efforts led to the discovery that adenosine kinase (ADK) inhibitors stimulate β-cell replication....

journal_title：Diabetes

authors： Navarro G,Abdolazimi Y,Zhao Z,Xu H,Lee S,Armstrong NA,Annes JP

更新日期：2017-07-01 00:00:00

abstract：:Current pharmacological options for type 2 diabetes do not cure the disease. Despite the availability of multiple drug classes that modulate glycemia effectively and minimize long-term complications, these agents do not reverse pathogenesis, and in practice they are not selected to correct the molecular profile specif...

journal_title：Diabetes

authors： Florez JC

更新日期：2017-07-01 00:00:00

abstract：:Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle and therefore represents an important alternative to stimulate glucose uptake in insulin-resistant muscle. Both Rac1 and AMPK have been shown to partly regulate contraction-stimulated muscle glucose uptake, but whether those two signali...

journal_title：Diabetes

authors： Sylow L,Møller LLV,Kleinert M,D'Hulst G,De Groote E,Schjerling P,Steinberg GR,Jensen TE,Richter EA

更新日期：2017-06-01 00:00:00

abstract：:GLUT4 is necessary for acute insulin- and contraction-induced skeletal muscle glucose uptake, but its role in chronic muscle loading (overload)-induced glucose uptake is unknown. Our goal was to determine whether GLUT4 is required for overload-induced glucose uptake. Overload was induced in mouse plantaris muscle by u...

journal_title：Diabetes

authors： McMillin SL,Schmidt DL,Kahn BB,Witczak CA

更新日期：2017-06-01 00:00:00

abstract：:Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige adipocyte differentiation are essential to implement such therapeutic strategies. We report a straightforward and efficient protocol to generate functional human be...

journal_title：Diabetes

authors： Guénantin AC,Briand N,Capel E,Dumont F,Morichon R,Provost C,Stillitano F,Jeziorowska D,Siffroi JP,Hajjar RJ,Fève B,Hulot JS,Collas P,Capeau J,Vigouroux C

更新日期：2017-06-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and two clinic-based cohorts. A custom Asian exome-chip was used to dete...

journal_title：Diabetes

authors： Cheung CYY,Tang CS,Xu A,Lee CH,Au KW,Xu L,Fong CHY,Kwok KHM,Chow WS,Woo YC,Yuen MMA,Cherny SS,Hai J,Cheung BMY,Tan KCB,Lam TH,Tse HF,Sham PC,Lam KSL

更新日期：2017-06-01 00:00:00

abstract：:We used hepatic balance and tracer ([3H]glucose) techniques to examine the impact of "breakfast" on hepatic glucose metabolism later in the same day. From 0-240 min, 2 groups of conscious dogs (n = 9 dogs/group) received a duodenal infusion of glucose (GLC) or saline (SAL), then were fasted from 240-360 min. Three dog...

journal_title：Diabetes

authors： Moore MC,Smith MS,Farmer B,Kraft G,Shiota M,Williams PE,Cherrington AD

更新日期：2017-05-01 00:00:00

abstract：:Low-grade sustained inflammation links obesity to insulin resistance and nonalcoholic fatty liver disease (NAFLD). However, therapeutic approaches to improve systemic energy balance and chronic inflammation in obesity are limited. Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) allevia...

journal_title：Diabetes

authors： Nagata N,Xu L,Kohno S,Ushida Y,Aoki Y,Umeda R,Fuke N,Zhuge F,Ni Y,Nagashimada M,Takahashi C,Suganuma H,Kaneko S,Ota T

更新日期：2017-05-01 00:00:00

abstract：:Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice from high-fat diet-i...

journal_title：Diabetes

authors： Meng W,Liang X,Chen H,Luo H,Bai J,Li G,Zhang Q,Xiao T,He S,Zhang Y,Xu Z,Xiao B,Liu M,Hu F,Liu F

更新日期：2017-05-01 00:00:00

abstract：:Hypoadiponectinemia has been widely observed in patients with gestational diabetes mellitus (GDM). To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq-/- ) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. Adenovira...

journal_title：Diabetes

authors： Qiao L,Wattez JS,Lee S,Nguyen A,Schaack J,Hay WW Jr,Shao J

更新日期：2017-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess immunoregulatory, anti-inflammatory, and proangiogenic properties and, therefore, have the potential to improve islet engraftment and survival. We assessed the effect human bone marrow-derived MSCs have on neonatal porcine islets (NPIs) in vitro and determined islet engraftment an...

journal_title：Diabetes

authors： Hayward JA,Ellis CE,Seeberger K,Lee T,Salama B,Mulet-Sierra A,Kuppan P,Adesida A,Korbutt GS

更新日期：2017-05-01 00:00:00

abstract：:Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD i...

journal_title：Diabetes

authors： Marshall AG,Lee-Kubli C,Azmi S,Zhang M,Ferdousi M,Mixcoatl-Zecuatl T,Petropoulos IN,Ponirakis G,Fineman MS,Fadavi H,Frizzi K,Tavakoli M,Jeziorska M,Jolivalt CG,Boulton AJM,Efron N,Calcutt NA,Malik RA

更新日期：2017-05-01 00:00:00

abstract：:The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest t...

journal_title：Diabetes

authors： Andersen DK,Korc M,Petersen GM,Eibl G,Li D,Rickels MR,Chari ST,Abbruzzese JL

更新日期：2017-05-01 00:00:00

abstract：:Sirt6 is an NAD+-dependent deacetylase that is involved in the control of energy metabolism. However, the tissue-specific function of Sirt6 in the adipose tissue remains unknown. In this study, we showed that fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to ad...

journal_title：Diabetes

authors： Kuang J,Zhang Y,Liu Q,Shen J,Pu S,Cheng S,Chen L,Li H,Wu T,Li R,Li Y,Zou M,Zhang Z,Jiang W,Xu G,Qu A,Xie W,He J

更新日期：2017-05-01 00:00:00

abstract：:Dietary methionine restriction (MR) produces a rapid and persistent remodeling of white adipose tissue (WAT), an increase in energy expenditure (EE), and enhancement of insulin sensitivity. Recent work established that hepatic expression of FGF21 is robustly increased by MR. Fgf21-/- mice were used to test whether FGF...

journal_title：Diabetes

authors： Wanders D,Forney LA,Stone KP,Burk DH,Pierse A,Gettys TW

更新日期：2017-04-01 00:00:00

abstract：:The current view of diabetic kidney disease, based on meticulously acquired ultrastructural morphometry and the utility of measuring plasma creatinine and urinary albumin, has been almost entirely focused on the glomerulus. While clearly of great importance, changes in the glomerulus are not the major determinant of r...

journal_title：Diabetes

authors： Gilbert RE

更新日期：2017-04-01 00:00:00

abstract：:Misregulated hormone secretion from the islet of Langerhans is central to the pathophysiology of diabetes. Although insulin plays a key role in glucose regulation, the importance of glucagon is increasingly acknowledged. However, the mechanisms that regulate glucagon secretion from α-cells are still unclear. We used p...

journal_title：Diabetes

authors： Reissaus CA,Piston DW

更新日期：2017-04-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:Müller cells and macrophages/microglia are likely important for the development of diabetic retinopathy; however, the interplay between these cells in this disease is not well understood. An inflammatory process is linked to the onset of experimental diabetic retinopathy. CD40 deficiency impairs this process and preve...

journal_title：Diabetes

authors： Portillo JC,Lopez Corcino Y,Miao Y,Tang J,Sheibani N,Kern TS,Dubyak GR,Subauste CS

更新日期：2017-02-01 00:00:00

abstract：:Although type 1 diabetes (T1D) is primarily perceived as a T cell-driven autoimmune disease, islet autoantibodies are the best currently available biomarker for autoimmunity and disease risk. These antibodies are produced by autoreactive B cells, the activation of which is largely dependent on the function of CD4+CXCR...

journal_title：Diabetes

authors： Viisanen T,Ihantola EL,Näntö-Salonen K,Hyöty H,Nurminen N,Selvenius J,Juutilainen A,Moilanen L,Pihlajamäki J,Veijola R,Toppari J,Knip M,Ilonen J,Kinnunen T

更新日期：2017-02-01 00:00:00

abstract：:Adults with diabetes are 2-4 times more likely to suffer from heart disease or ischemic stroke than adults without diabetes, yet standard antiplatelet therapy, which is the cornerstone for primary and secondary prevention of cardiovascular disease, fails in many patients with diabetes. Three independent but often inte...

journal_title：Diabetes

authors： Arthur JF,Jandeleit-Dahm K,Andrews RK

更新日期：2017-01-01 00:00:00

abstract：:Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, ...

journal_title：Diabetes

authors： Bamberg F,Hetterich H,Rospleszcz S,Lorbeer R,Auweter SD,Schlett CL,Schafnitzel A,Bayerl C,Schindler A,Saam T,Müller-Peltzer K,Sommer W,Zitzelsberger T,Machann J,Ingrisch M,Selder S,Rathmann W,Heier M,Linkohr B,Meisi

更新日期：2017-01-01 00:00:00